This post is part of a series into Sjogren's treatments and side effects.
Hydroxychloroquine HCQ (Plaquenil) is an immunomodulatory drug. Instead of suppressing the immune system, HCQ alters the way the immune system works. The drug reduces levels of type-1 interferon (IFN) and reduces interferon-stimulated gene expression (ISG). As such, it improves the way Sjögren’s patients’ immune system works and thereby improves Sjögren’s symptoms.
Usually, it is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve over time.
According to Dr. Thomas at the Sjögren’s Foundation, it is important to get two eye tests done every year to make sure that it doesn’t cause any eye problems. It is best to get both a visual field 10-2 and an SD-OCT test done yearly.
Common side effects of Plaquenil, according to RxList, include
- nausea,
- vomiting,
- stomach pain or cramps,
- loss of appetite,
- weight loss,
- diarrhea,
- dizziness,
- spinning sensation,
- headache,
- ringing in your ears,
- mood changes,
- nervousness,
- irritability,
- skin rash,
- itching, or
- hair loss.
Obviously, if you have any of these symptoms you should let your doctor know as soon as possible.
Please note that hydroxychloroquine (Plaquenil) does NOT suppress your immune system and does not increase any risk for a more serious illness from COVID-19. However, all Sjögren’s patients should still be diligent and be tested if symptoms become present.
MORE ABOUT HYDROXYCHLOROQUINE:
Hydroxychloroquine is used to prevent and treat malaria. It may also be prescribed to treat rheumatoid arthritis, lupus, and post Lyme arthritis. It was created in 1934 as a treatment for malaria as an alternative to quinine. It was first used by doctors for malaria in 1947.
Brand names of hydroxychloroquine include Plaquenil, Hydroquin, Axemal, Dolquine, Quensyl, and Quinoric.
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