RECENT SJOGREN'S RESEARCH: Effect of the Chinese Herbal Medicine SS-1 on a Sjögren’s Syndrome-Like Disease in Mice

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Effect of the Chinese Herbal Medicine SS-1 on a Sjögren’s Syndrome-Like Disease

The Chinese herbal formula is composed of Gan Lu Yin, Sang Ju Yin, and Xuefu Zhuyu.

It has anti-inflammatory, immunomodulatory, and antifibrotic (reduces fibrosis) effects.

The researchers previous study showed that SS-1 alleviates clinical Sjogren's syndrome (SS).

This new study aimed to evaluate the effectiveness of the Chinese herbal formula for salivary gland protein-induced experimental Sjögren’s syndrome (ESS).

The results showed treatment with the Chinese herbal formula significantly alleviated the severity of ESS:
  • substantially improved saliva flow rates
  • reduced the number of antibody-producing immune cells that infiltrated the submandibular glands
  • lowered proinflammatory cytokines 
  • decreased serum anti-M3R autoantibody levels
"Our data show that SS-1 alleviates ESS through anti-inflammatory and immunomodulatory effects, which provides new insight into the clinical treatment of SS."

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