RECENT SJOGREN'S RESEARCH: Effect of the Chinese Herbal Medicine SS-1 on a Sjögren’s Syndrome-Like Disease in Mice
The Chinese herbal formula is composed of Gan Lu Yin, Sang Ju Yin, and Xuefu Zhuyu.
It has anti-inflammatory, immunomodulatory, and antifibrotic (reduces fibrosis) effects.
The researchers previous study showed that SS-1 alleviates clinical Sjogren's syndrome (SS).
This new study aimed to evaluate the effectiveness of the Chinese herbal formula for salivary gland protein-induced experimental Sjögren’s syndrome (ESS).
The results showed treatment with the Chinese herbal formula significantly alleviated the severity of ESS:
- substantially improved saliva flow rates
- reduced the number of antibody-producing immune cells that infiltrated the submandibular glands
- lowered proinflammatory cytokines
- decreased serum anti-M3R autoantibody levels
"Our data show that SS-1 alleviates ESS through anti-inflammatory and immunomodulatory effects, which provides new insight into the clinical treatment of SS."
This study is significant for people living with Sjögren’s disease because it offers promising evidence that the Chinese herbal formula SS-1 may help address some of the most debilitating symptoms of the condition—particularly dry mouth and immune-driven glandular damage.
By demonstrating improved saliva flow, reduced immune cell infiltration in the salivary glands, and lowered levels of inflammatory markers and autoantibodies, the research suggests SS-1 could offer a multi-pronged therapeutic approach. Its anti-inflammatory, immunomodulatory, and antifibrotic properties are especially relevant for those seeking alternatives to conventional treatments, which often come with limited efficacy or unwanted side effects.
For sufferers navigating the daily discomfort and systemic impact of Sjögren’s, this study provides a hopeful glimpse into integrative options that may support both symptom relief and immune regulation.
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